Valore aggiunto alle nostre strade

Si viene determinando l’esigenza di riflettere sulla necessità di decidere quale funzione assegnare ai diversi elementi dei patrimoni esistenti quando si pensi alla progettazione di nuove opere. La finalità che ci si prefigge, in attesa di Norme specifiche per l’adeguamento di infrastrutture viarie esistenti, è formulare proposte per l’adattamento della Normativa vigente al tema progettuale in questione

L???adeguamento del patrimonio infrastrutturale esistente

Il nostro Paese ha un'orografia complessa ed è caratterizzato da un sistema insediativo composto per lo più da città di medie dimensioni, da paesi e da borghi, formatosi in un territorio prealpino, appenninico, e comunque collinare come nelle Isole maggiori, tutti accomunati dalla presenza di emergenze storico-ambientali, testimonianza di una storia plurisecolare. A questo dato territoriale, corrisponde un patrimonio stradale costituito, solo nella misura del 4% (circa 7.000 km), da strade a carreggiate separate, assimilabili al tipo autostradale, e quindi prevalentemente composto da strade a carreggiata unica, appartenenti a differenti Enti ed Amministrazioni, spesso inadeguate in termini di sicurezza della circolazione

Ferromagnetic features on zero-bias conductance peaks in ferromagnet/insulator/superconductor junction

We present a formula for tunneling conductance in ballistic ferromagnet/ferromagnetic insulator/superconductor junctions where the superconducting state has opposite spin pairing symmetry. The formula can involve correctly a ferromagnetism has been induced by effective mass difference between up- and down-spin electrons. Then, this effective mass mismatch ferromagnet and standard Stoner ferromagnet have been employed in this paper. As an application of the formulation, we have studied the tunneling effect for junctions including spin-triplet p-wave superconductor. The conductace spectra show a clear difference between two ferromagnets depending upon the way of normalization of the conductance. Especially, a essential difference is seen in zero-bias conductance peaks reflecting characteristics of each ferromagnets. From obtained results, it will be suggested that the measurements of the tunneling conductance in the junction provide us a useful information about the mechanism of itinerant ferromagnetism in metal.Comment: 8 pages, 8 figures, references added to the first versio

Preventing Household Food Waste in Italy: A Segmentation of the Population and Suggestions for Action

Household food waste represents one of the main challenges threatening the sustainability of modern food systems globally. As is widely recognised, a deeper understanding of wasteful behaviour profiles is the starting point of designing intervention strategies. The overall objective of this research is to explore the role of psychological factors that influence household wasteful food behaviour in Italy and to profile consumers with heterogeneous personal attitudes towards wasting food. Starting with data collected through a web-based survey realized on a sample of 530 individuals responsible for household shopping, a principal component analysis and a two-step cluster analysis revealed three different segments of consumers with heterogeneous wasteful behaviours. The clusters differ in relation to psychological factors, such as moral attitudes and concerns about and intentions to reduce food waste. The study findings provide insights for implementing prevention, reduction, and recovery strategies tailored to these different consumer profiles

The role of Akt signalling in the mammalian ovary

The serine/threonine protein kinase Akt is involved in many cellular processes including cell growth, survival, proliferation and metabolism. Akt activity is modulated downstream of phosphatidylinositol-3-kinase (PI3K) in response to different extracellular stimuli. In the mammalian ovary, Akt collaborates with other kinases in the regulation of coordinate follicle and oocyte development. Akt determines the pool of primordial follicles and the transition from quiescent to growing phase. In addition, the kinase modulates granulosa cell apoptosis throughout folliculogenesis. In oocytes Akt participates in the control of meiosis resumption and, at metaphase II stage, regulates polar body emission and spindle organization. Its inhibition negatively affects preimplantation embryo development. As a consequence of such a central role, Akt dysregulation is associated with several human diseases including infertility and ovarian cancer.[...

Niobium superconducting nanowire single-photon detectors

We investigate the performance of superconducting nanowire photon detectors fabricated from ultra-thin Nb. A direct comparison is made between these detectors and similar nanowire detectors fabricated from NbN. We find that Nb detectors are significantly more susceptible than NbN to thermal instability (latching) at high bias. We show that the devices can be stabilized by reducing the input resistance of the readout. Nb detectors optimized in this way are shown to have approximately 2/3 the reset time of similar large-active-area NbN detectors of the same geometry, with approximately 6% detection efficiency for single photons at 470 nm

Random Graph-Homomorphisms and Logarithmic Degree

A graph homomorphism between two graphs is a map from the vertex set of one graph to the vertex set of the other graph, that maps edges to edges. In this note we study the range of a uniformly chosen homomorphism from a graph G to the infinite line Z. It is shown that if the maximal degree of G is `sub-logarithmic', then the range of such a homomorphism is super-constant. Furthermore, some examples are provided, suggesting that perhaps for graphs with super-logarithmic degree, the range of a typical homomorphism is bounded. In particular, a sharp transition is shown for a specific family of graphs C_{n,k} (which is the tensor product of the n-cycle and a complete graph, with self-loops, of size k). That is, given any function psi(n) tending to infinity, the range of a typical homomorphism of C_{n,k} is super-constant for k = 2 log(n) - psi(n), and is 3 for k = 2 log(n) + psi(n)

Multistep, sequential control of the trafficking and function of the multiple sulfatase deficiency gene product, SUMF1 by PDI, ERGIC-53 and ERp44.

Sulfatase modifying factor 1 (SUMF1) encodes for the formylglicine generating enzyme, which activates sulfatases by modifying a key cysteine residue within their catalytic domains. SUMF1 is mutated in patients affected by multiple sulfatase deficiency, a rare recessive disorder in which all sulfatase activities are impaired. Despite the absence of canonical retention/retrieval signals, SUMF1 is largely retained in the endoplasmic reticulum (ER), where it exerts its enzymatic activity on nascent sulfatases. Part of SUMF1 is secreted and paracrinally taken up by distant cells. Here we show that SUMF1 interacts with protein disulfide isomerase (PDI) and ERp44, two thioredoxin family members residing in the early secretory pathway, and with ERGIC-53, a lectin that shuttles between the ER and the Golgi. Functional assays reveal that these interactions are crucial for controlling SUMF1 traffic and function. PDI couples SUMF1 retention and activation in the ER. ERGIC-53 and ERp44 act downstream, favoring SUMF1 export from and retrieval to the ER, respectively. Silencing ERGIC-53 causes proteasomal degradation of SUMF1, while down-regulating ERp44 promotes its secretion. When over-expressed, each of three interactors favors intracellular accumulation. Our results reveal a multistep control of SUMF1 trafficking, with sequential interactions dynamically determining ER localization, activity and secretion

An overview of coumarin as a versatile and readily accessible scaffold with broad-ranging biological activities

Privileged structures have been widely used as an effective template for the research and discovery of high value chemicals. Coumarin is a simple scaffold widespread in Nature and it can be found in a considerable number of plants as well as in some fungi and bacteria. In the last years, these natural compounds have been gaining an increasing attention from the scientific community for their wide range of biological activities, mainly due to their ability to interact with diverse enzymes and receptors in living organisms. In addition, coumarin nucleus has proved to be easily synthetized and decorated, giving the possibility of designing new coumarin-based compounds and investigating their potential in the treatment of various diseases. The versatility of coumarin scaffold finds applications not only in medicinal chemistry but also in the agrochemical field as well as in the cosmetic and fragrances industry. This review is intended to be a critical overview on coumarins, comprehensive of natural sources, metabolites, biological evaluations and synthetic approaches